77500BRJob Posting Title:Research Assistant IDepartment:Pediatrics-Pulmonary AutoReqId:77500BRStatus:Full-TimeStandard Hours per Week:40 Job Posting Category:ResearchJob Posting Description:Job Description and General Summary The Park Lab at Boston Childrens Hospital, Harvard Medical School is seeking highly motivated applicants for the position of Research Assistant in the lab. We identify and define key mechanisms whereby extracellular matrix (ECM) components regulate molecular and cellular processes that control the onset, progression, and outcome of acute and chronic inflammatory disease. For example, we found that proteoglycans inhibit innate immune responses in the lung, cornea, and liver to limit inflammatory tissue injury, but that certain pathogens exploit these fundamental functions of proteoglycans to inhibit immune clearance and promote their pathogenesis. We are interested in cell-matrix and host-pathogen interactions that shape immune responses, tissue repair processes, and matrix remodeling mechanisms. Research in the Park Lab is multidisciplinary and takes advantage of genetically modified mice, primary cell cultures, engineered cell lines, high throughput technologies and diagnostics, and a wide range of molecular, biochemical, cellular, microbiological, glycobiological, structural, and histological techniques. The Research Assistant will be responsible for:
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